Co-administration of GF120918 significantly increases the systemic exposure to oral paclitaxel in cancer patients

Oral bioavailability of paclitaxel is very low, which is due to efficient transport of the drug by the intestinal drug efflux pump P-glycoprotein (P-gp). We have recently demonstrated that the oral bioavailability of paclitaxel can be increased at least 7-fold by co-administration of the P-gp blocke...

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Bibliographic Details
Main Authors: Malingré, M M, Beijnen, J H, Rosing, H, Koopman, F J, Jewell, R C, Paul, E M, Huinink, W W Ten Bokkel, Schellens, J H M
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2001
Subjects:
Regular Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363627/
https://ncbi.nlm.nih.gov/pubmed/11139311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2000.1543
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