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Assessment of the relationship between genotypic status of a DT-diaphorase point mutation and enzymatic activity
DT-diaphorase, a cytosolic reductase, has been implicated as an activator of chemotherapeutic prodrugs and a detoxifier of certain potentially carcinogenic xenobiotics. A common C to T nucleotide 609 substitution in DT-diaphorase cDNA has been associated with protein instability and reduced catalyti...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group
2000
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2363567/ https://ncbi.nlm.nih.gov/pubmed/10993645 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2000.1359 |
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