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Deoxyuridine triphosphatase (dUTPase) expression and sensitivity to the thymidylate synthase (TS) inhibitorD9331

Uracil DNA misincorporation and misrepair of DNA have been recognized as important events accompanying thymidylate synthase (TS) inhibition. dUTPase catalyses the hydrolysis of dUTP to dUMP, thereby maintaining low intracellular dUTP. We have addressed the relationship between dUTPase expression and...

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書誌詳細
主要な著者: Webley, S D, Hardcastle, A, Ladner, R D, Jackman, A L, Aherne, G W
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2000
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363540/
https://ncbi.nlm.nih.gov/pubmed/10952785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2000.1358
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