Induction of thymidine phosphorylase as a pharmacodynamic end-point in patients with advanced carcinoma treated with 5-fluorouracil, folinic acid and interferon alpha

Thymidine phosphorylase (TP) is an essential enzyme for the biochemical activation of 5-fluorouracil (5-FU). Interferon upregulates TP in vivo, although the dose and schedule of interferon for optimal biomodulation of 5-FU is not known. In this study, TP activity was measured in peripheral blood lym...

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Main Authors: Braybrooke, J P, Propper, D J, O’Byrne, K J, Koukourakis, M I, Patterson, A V, Houlbrook, S, Love, S D, Varcoe, S, Taylor, M, Ganesan, T S, Talbot, D C, Harris, A L
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2000
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Regular Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363491/
https://ncbi.nlm.nih.gov/pubmed/10901374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2000.1230
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