In vitro analysis of virus-associated RNA I (VAI RNA): inhibition of the double-stranded RNA-activated protein kinase PKR by VAI RNA mutants correlates with the in vivo phenotype and the structural integrity of the central domain.

Adenoviruses use the virus-encoded virus-associated RNA (VAI RNA) as a defense against cellular antiviral response by blocking the activation of the interferon-induced, double-stranded RNA-activated protein kinase PKR. The structure of VAI RNA consists of two long, imperfectly base-paired duplex reg...

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Detalles Bibliográficos
Publicado en:J Virol
Autores principales: Ghadge, G D, Malhotra, P, Furtado, M R, Dhar, R, Thimmapaya, B
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 1994
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC236337/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7911532/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.68.7.4137-4151.1994
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