Microsatellite instability and mismatch repair gene inactivation in sporadic pancreatic and colon tumours

Genomic instability has been proposed as a new mechanism of carcinogenesis involved in hereditary non-polyposis colorectal cancer (HNPCC) and in a large number of sporadic cancers like pancreatic and colon tumours. Mutations in human mismatch repair genes have been found in HNPCC patients, but their...

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Main Authors: Ghimenti, C, Tannergård, P, Wahlberg, S, Liu, T, Giulianotti, P G, Mosca, F, Fornaciari, G, Bevilacqua, G, Lindblom, A, Caligo, M A
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 1999
Fag:
Regular Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2363009/
https://ncbi.nlm.nih.gov/pubmed/10389971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690314
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