Potent interaction of flavopiridol with MRP1

The multidrug resistance protein 1 (MRP1) is an ATP-dependent transport protein for organic anions, as well as neutral or positively charged anticancer agents. In this study we show that flavopiridol, a synthetic flavonoid currently studied in phase 1 trials for its anti-proliferative characteristic...

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Bibliografiske detaljer
Main Authors: Hooijberg, J H, Broxterman, H J, Scheffer, G L, Vrasdonk, C, Heijn, M, Jong, M C de, Scheper, R J, Lankelma, J, Pinedo, HM
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 1999
Fag:
Regular Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2362861/
https://ncbi.nlm.nih.gov/pubmed/10496352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690687
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