Potentiation of anti-cancer drug activity at low intratumoral pH induced by the mitochondrial inhibitor m-iodobenzylguanidine (MIBG) and its analogue benzylguanidine (BG)

Tumour-selective acidification is of potential interest for enhanced therapeutic gain of pH sensitive drugs. In this study, we investigated the feasibility of a tumour-selective reduction of the extracellular and intracellular pH and their effect on the tumour response of selected anti-cancer drugs....

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Detalhes bibliográficos
Main Authors: Kuin, A, Aalders, M, Lamfers, M, Zuidam, D J van, Essers, M, Beijnen, J H, Smets, L A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1999
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2362690/
https://ncbi.nlm.nih.gov/pubmed/10070871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690127
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