ICP34.5 mutants of herpes simplex virus type 1 strain 17syn+ are attenuated for neurovirulence in mice and for replication in confluent primary mouse embryo cell cultures.

In a recent report, the neurovirulence of herpes simplex virus type 1 (HSV-1) was mapped to the ICP34.5 gene (J. Chou, E. R. Kern, R. J. Whitley, and B. Roizman, Science 250:1262-1266, 1990). In this report, specific mutations within ICP34.5 were constructed in HSV-1 strain 17syn+ to determine the e...

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Bibliographic Details
Published in:J Virol
Main Authors: Bolovan, C A, Sawtell, N M, Thompson, R L
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1994
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC236262/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8254758/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.68.1.48-55.1994
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