Enhancement of membrane-type 1-matrix metalloproteinase (MT1-MMP) production and sequential activation of progelatinase A on human squamous carcinoma cells co-cultured with human dermal fibroblasts

Matrix metalloproteinase 2 (MMP-2)/gelatinase A plays an important role in tumour invasion and metastasis. Since MMP-2 is secreted as an inactive form (proMMP-2) from tumour and neighbouring stroma cells, the activation process is necessary to express the enzymic activity for degradation of extracel...

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Detalhes bibliográficos
Main Authors: Sato, T, Iwai, M, Sakai, T, Sato, H, Seiki, M, Mori, Y, Ito, A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1999
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2362364/
https://ncbi.nlm.nih.gov/pubmed/10376963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690477
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