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Caspase-3 activation during apoptosis caused by glutathione–doxorubicin conjugate
Glutathione–doxorubicin (GSH–DXR) effectively induced apoptosis in rat hepatoma cells (AH66) at a lower concentration than DXR. After 24 h of drug treatment, DNA fragmentation of the cells was observed at the concentration of 1.0 μM DXR or 0.01 μM GSH–DXR. Increase in caspase-3 activity and DNA frag...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
1999
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2362273/ https://ncbi.nlm.nih.gov/pubmed/10360648 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690414 |
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