Caspase-3 activation during apoptosis caused by glutathione–doxorubicin conjugate

Glutathione–doxorubicin (GSH–DXR) effectively induced apoptosis in rat hepatoma cells (AH66) at a lower concentration than DXR. After 24 h of drug treatment, DNA fragmentation of the cells was observed at the concentration of 1.0 μM DXR or 0.01 μM GSH–DXR. Increase in caspase-3 activity and DNA frag...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Asakura, T, Sawai, T, Hashidume, Y, Ohkawa, Y, Yokoyama, S, Ohkawa, K
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 1999
Gaiak:
Regular Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2362273/
https://ncbi.nlm.nih.gov/pubmed/10360648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690414
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