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Mechanisms of relapse in acute leukaemia: involvement of p53 mutated subclones in disease progression in acute lymphoblastic leukaemia

Mutations of the p53 tumour suppressor gene are infrequent at presentation of both acute myeloblastic leukaemia (AML) and acute lymphoblastic leukaemia (ALL), being found in between 5–10% of AML and 2–3% of ALL. Here we have studied the frequency of detection of p53 mutations at relapse of both AML...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zhu, Y-M, Foroni, L, McQuaker, I G, Papaioannou, M, Haynes, A, Russell, H H
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 1999
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2362216/
https://ncbi.nlm.nih.gov/pubmed/10098750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690183
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