Pharmacodynamics of cisplatin in human head and neck cancer: correlation between platinum content, DNA adduct levels and drug sensitivity in vitro and in vivo

Total platinum contents and cisplatin–DNA adduct levels were determined in vivo in xenografted tumour tissues in mice and in vitro in cultured tumour cells of head and neck squamous cell carcinoma (HNSCC), and correlated with sensitivity to cisplatin. In vivo, a panel of five HNSCC tumour lines grow...

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Detalhes bibliográficos
Main Authors: Welters, M J P, Fichtinger-Schepman, A M J, Baan, R A, Jacobs-Bergmans, A J, Kegel, A, van der Vijgh, W J F, Braakhuis, B J M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1999
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2362173/
https://ncbi.nlm.nih.gov/pubmed/10408697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690015
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