Pharmacodynamics of cisplatin in human head and neck cancer: correlation between platinum content, DNA adduct levels and drug sensitivity in vitro and in vivo

Total platinum contents and cisplatin–DNA adduct levels were determined in vivo in xenografted tumour tissues in mice and in vitro in cultured tumour cells of head and neck squamous cell carcinoma (HNSCC), and correlated with sensitivity to cisplatin. In vivo, a panel of five HNSCC tumour lines grow...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Welters, M J P, Fichtinger-Schepman, A M J, Baan, R A, Jacobs-Bergmans, A J, Kegel, A, van der Vijgh, W J F, Braakhuis, B J M
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 1999
Schlagworte:
Regular Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2362173/
https://ncbi.nlm.nih.gov/pubmed/10408697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690015
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