Reduction of PTEN protein and loss of epidermal growth factor receptor gene mutation in lung cancer with natural resistance to gefitinib (IRESSA)

Gefitinib (IRESSA), an epidermal growth factor receptor (EGFR) tyrosine kinase (TK) inhibitor, has antitumour activity in the advanced non-small-cell lung cancer (NSCLC) setting. However, in chemotherapy-naïve patients with advanced NSCLC, the addition of gefitinib to standard chemotherapy regimens...

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Detalhes bibliográficos
Main Authors: Kokubo, Y, Gemma, A, Noro, R, Seike, M, Kataoka, K, Matsuda, K, Okano, T, Minegishi, Y, Yoshimura, A, Shibuya, M, Kudoh, S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2005
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2362053/
https://ncbi.nlm.nih.gov/pubmed/15870831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602559
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