Immunosuppressive effects of radiation on human dendritic cells: reduced IL-12 production on activation and impairment of naïve T-cell priming

Dendritic cells (DC) are professional antigen-presenting cells (APC) of the immune system, uniquely able to prime naïve T-cell responses. They are the focus of a range of novel strategies for the immunotherapy of cancer, a proportion of which include treating DC with ionising radiation to high dose....

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Detalhes bibliográficos
Main Authors: Merrick, A, Errington, F, Milward, K, O'Donnell, D, Harrington, K, Bateman, A, Pandha, H, Vile, R, Morrison, E, Selby, P, Melcher, A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2005
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2362011/
https://ncbi.nlm.nih.gov/pubmed/15812550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602518
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