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MET signalling in primary colon epithelial cells leads to increased transformation irrespective of aberrant Wnt signalling

It has been shown that in hereditary and most sporadic colon tumours, components of the Wnt pathway are mutated. The Wnt target MET has been implicated in the development of colon cancer. Here, we show that overexpression of wild-type or a constitutively activated form of MET in colon epithelial cel...

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Autori principali: Boon, E M J, Kovarikova, M, Derksen, P W B, van der Neut, R
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2005
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361927/
https://ncbi.nlm.nih.gov/pubmed/15785735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602405
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