Synergistic growth inhibition by Iressa and Rapamycin is modulated by VHL mutations in renal cell carcinoma

Epidermal growth factor receptor (EGFR) and tumour growth factor alpha (TGFα) are frequently overexpressed in renal cell carcinoma (RCC) yet responses to single-agent EGFR inhibitors are uncommon. Although von Hippel–Lindau (VHL) mutations are predominant, RCC also develops in individuals with tuber...

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Bibliografiske detaljer
Main Authors: Gemmill, R M, Zhou, M, Costa, L, Korch, C, Bukowski, R M, Drabkin, H A
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2005
Fag:
Genetics and Genomics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361810/
https://ncbi.nlm.nih.gov/pubmed/15956968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602646
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