A phase I pharmacokinetic and pharmacodynamic study of BGC9331 and carboplatin in relapsed gynaecological malignancies

BGC9331 is a rationally designed, specific nonpolyglutamatable thymidylate synthase (TS) inhibitor that is active in gynaecological malignancies. In the light of the sensitivity of human ovarian tumour cell lines to BGC9331 and non-cross resistance to platinum drugs, we studied the combination BGC93...

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Hlavní autoři: Benepal, T, Jackman, A, Pyle, L, Bate, S, Hardcastle, A, Aherne, W, Mitchell, F, Simmons, L, Ruddle, R, Raynaud, F, Gore, M
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2005
Témata:
Clinical Study
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361661/
https://ncbi.nlm.nih.gov/pubmed/16222320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602811
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