Genetic and epigenetic changes in primary metastatic and nonmetastatic colorectal cancer

Colorectal cancer (CRC) develops as multistep process, which involves genetic and epigenetic alterations. K-Ras, p53 and B-Raf mutations and RASSF1A, E-Cadherin and p16INK4A promoter methylation were investigated in 202 CRCs with and without lymph node and/or liver metastasis, to assess whether gene...

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Главные авторы: Miranda, E, Destro, A, Malesci, A, Balladore, E, Bianchi, P, Baryshnikova, E, Franchi, G, Morenghi, E, Laghi, L, Gennari, L, Roncalli, M
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2006
Предметы:
Genetics and Genomics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2360724/
https://ncbi.nlm.nih.gov/pubmed/16969349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6603337
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