TIMP-1 gene deficiency increases tumour cell sensitivity to chemotherapy-induced apoptosis

Tissue inhibitor of metalloproteinases-1 (TIMP-1) is one of four inhibitors of the matrix metalloproteinases, which are capable of degrading most components of the extracellular matrix. However, in recent years, TIMP-1 has been recognised as a multifunctional protein, playing a complex role in cance...

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Main Authors: Davidsen, M L, Würtz, SØ, Rømer, M U, Sørensen, N M, Johansen, S K, Christensen, I J, Larsen, J K, Offenberg, H, Brünner, N, Lademann, U
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2006
Fag:
Genetics and Genomics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2360707/
https://ncbi.nlm.nih.gov/pubmed/17047657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6603378
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