Moxifloxacin enhances antiproliferative and apoptotic effects of etoposide but inhibits its proinflammatory effects in THP-1 and Jurkat cells

Etoposide (VP-16) is a topoisomerase II (topo II) inhibitor chemotherapeutic agent. Studies indicate that VP-16 enhances proinflammatory cytokines secretion from tumour cells, including IL-8, a chemokine associated with proangiogenic effects. Fluoroquinolones inhibit topo II activity in eukaryotic c...

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Bibliographic Details
Main Authors: Fabian, I, Reuveni, D, Levitov, A, Halperin, D, Priel, E, Shalit, I
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2006
Subjects:
Translational Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2360706/
https://ncbi.nlm.nih.gov/pubmed/17047652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6603355
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