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Structural evidence for a second sialic acid binding site in avian influenza virus neuraminidases

The x-ray structure of a complex of sialic acid (Neu5Ac) with neuraminidase N9 subtype from A/tern/Australia/G70C/75 influenza virus at 4°C has revealed the location of a second Neu5Ac binding site on the surface of the enzyme. At 18°C, only the enzyme active site contains bound Neu5Ac. Neu5Ac binds...

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Detalhes bibliográficos
Main Authors: Varghese, Joseph N., Colman, Peter M., van Donkelaar, Albertus, Blick, Tony J., Sahasrabudhe, Anjali, McKimm-Breschkin, Jennifer L.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences of the USA 1997
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC23599/
https://ncbi.nlm.nih.gov/pubmed/9342319
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