Structural evidence for a second sialic acid binding site in avian influenza virus neuraminidases

The x-ray structure of a complex of sialic acid (Neu5Ac) with neuraminidase N9 subtype from A/tern/Australia/G70C/75 influenza virus at 4°C has revealed the location of a second Neu5Ac binding site on the surface of the enzyme. At 18°C, only the enzyme active site contains bound Neu5Ac. Neu5Ac binds...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Varghese, Joseph N., Colman, Peter M., van Donkelaar, Albertus, Blick, Tony J., Sahasrabudhe, Anjali, McKimm-Breschkin, Jennifer L.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23599/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9342319/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.22.11808
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