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Calculation of protein–ligand binding free energy by using a polarizable potential

The binding of charged ligands benzamidine and diazamidine to trypsin was investigated by using a polarizable potential energy function and explicit-water molecular dynamics simulations. The binding free energies were computed from the difference between the free energies of decoupling the ligand fr...

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Bibliografiske detaljer
Main Authors: Jiao, Dian, Golubkov, Pavel A., Darden, Thomas A., Ren, Pengyu
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2359813/
https://ncbi.nlm.nih.gov/pubmed/18427113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711686105
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