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Trypsin-Ligand Binding Free Energy Calculation with AMOEBA

The binding free energies of several benzamidine-like inhibitors to trypsin were examined using a polarizable potential. All the computed binding free energies are in good agreement with the experimental data. From free energy decomposition, electrostatic interaction was found to be the driving forc...

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Detalhes bibliográficos
Main Authors: Shi, Yue, Jiao, Dian, Schnieders, Michael J., Ren, Pengyu
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2819397/
https://ncbi.nlm.nih.gov/pubmed/19965178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1109/IEMBS.2009.5335108
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