Molecular architecture of Gα(o) and the structural basis for RGS16-mediated deactivation

Heterotrimeric G proteins relay extracellular cues from heptahelical transmembrane receptors to downstream effector molecules. Composed of an α subunit with intrinsic GTPase activity and a βγ heterodimer, the trimeric complex dissociates upon receptor-mediated nucleotide exchange on the α subunit, e...

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Hlavní autoři: Slep, Kevin C., Kercher, Michele A., Wieland, Thomas, Chen, Ching-Kang, Simon, Melvin I., Sigler, Paul B.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2008
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2359805/
https://ncbi.nlm.nih.gov/pubmed/18434540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0801569105
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