DNA synthesis from unbalanced nucleotide pools causes limited DNA damage that triggers ATR-CHK1-dependent p53 activation

p53-dependent G(1) and G(2) cell cycle checkpoints are activated in response DNA damage that help to maintain genomic stability. p53 also helps to protect cells from damage that occurs during S phase, for example, when the cells are starved for DNA precursors or irradiated with a low dose of UV. p53...

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Autors principals: Hastak, Kedar, Paul, Rajib K., Agarwal, Mukesh K., Thakur, Vijay S., Amin, A. R. M. Ruhul, Agrawal, Sudesh, Sramkoski, R. Michael, Jacobberger, James W., Jackson, Mark W., Stark, George R., Agarwal, Munna L.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2008
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2359797/
https://ncbi.nlm.nih.gov/pubmed/18434539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802080105
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