DNA synthesis from unbalanced nucleotide pools causes limited DNA damage that triggers ATR-CHK1-dependent p53 activation

p53-dependent G(1) and G(2) cell cycle checkpoints are activated in response DNA damage that help to maintain genomic stability. p53 also helps to protect cells from damage that occurs during S phase, for example, when the cells are starved for DNA precursors or irradiated with a low dose of UV. p53...

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Detalhes bibliográficos
Main Authors: Hastak, Kedar, Paul, Rajib K., Agarwal, Mukesh K., Thakur, Vijay S., Amin, A. R. M. Ruhul, Agrawal, Sudesh, Sramkoski, R. Michael, Jacobberger, James W., Jackson, Mark W., Stark, George R., Agarwal, Munna L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2359797/
https://ncbi.nlm.nih.gov/pubmed/18434539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802080105
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