p53-dependent p21-mediated growth arrest pre-empts and protects HCT116 cells from PUMA-mediated apoptosis induced by EGCG

The tumor suppressor protein p53 plays a key role in regulation of negative cellular growth in response to EGCG. To further explore the role of p53 signaling and elucidate the molecular mechanism, we employed colon cancer HCT116 cell line and its derivatives in which a specific transcriptional targe...

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Main Authors: Thakur, Vijay S, Amin, A.R.M. Ruhul, Paul, Rajib K, Gupta, Kalpana, Hastak, Kedar, Agarwal, Mukesh K, Jackson, Mark W, Wald, David N, Mukhtar, Hasan, Agarwal, Munna L
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2914167/
https://ncbi.nlm.nih.gov/pubmed/20444544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2010.04.012
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