p53-dependent p21-mediated growth arrest pre-empts and protects HCT116 cells from PUMA-mediated apoptosis induced by EGCG

The tumor suppressor protein p53 plays a key role in regulation of negative cellular growth in response to EGCG. To further explore the role of p53 signaling and elucidate the molecular mechanism, we employed colon cancer HCT116 cell line and its derivatives in which a specific transcriptional targe...

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Detalhes bibliográficos
Main Authors: Thakur, Vijay S, Amin, A.R.M. Ruhul, Paul, Rajib K, Gupta, Kalpana, Hastak, Kedar, Agarwal, Mukesh K, Jackson, Mark W, Wald, David N, Mukhtar, Hasan, Agarwal, Munna L
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2914167/
https://ncbi.nlm.nih.gov/pubmed/20444544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2010.04.012
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