Itch(−/−)αβ and γδ T cells independently contribute to autoimmunity in Itchy mice

E3 ubiquitin ligases determine which intracellular proteins are targets of the ubiquitin conjugation pathway and thus play a key role in determining the half-life, subcellular localization and/or activation status of their target proteins. Itchy mice lack the E3 ligase, Itch, and show dysregulation...

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Bibliographic Details
Main Authors: Parravicini, Valentino, Field, Anne-Christine, Tomlinson, Peter D., Albert Basson, M., Zamoyska, Rose
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2008
Subjects:
Immunobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2359485/
https://ncbi.nlm.nih.gov/pubmed/18256323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-10-115667
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