The interaction of the general anesthetic etomidate with the γ-aminobutyric acid type A receptor is influenced by a single amino acid

The γ-aminobutyric acid type A (GABA(A)) receptor is a transmitter-gated ion channel mediating the majority of fast inhibitory synaptic transmission within the brain. The receptor is a pentameric assembly of subunits drawn from multiple classes (α(1–6), β(1–3), γ(1–3), δ(1), and ɛ(1)). Positive allo...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Belelli, Delia, Lambert, Jeremy J., Peters, John A., Wafford, Keith, Whiting, Paul J.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1997
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23576/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9380754/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.20.11031
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