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Ca(2+)-independent inhibition of inositol trisphosphate receptors by calmodulin: Redistribution of calmodulin as a possible means of regulating Ca(2+) mobilization

The interactions between calmodulin, inositol 1,4,5-trisphosphate (InsP(3)), and pure cerebellar InsP(3) receptors were characterized by using a scintillation proximity assay. In the absence of Ca(2+), (125)I-labeled calmodulin reversibly bound to multiple sites on InsP(3) receptors and Ca(2+) incre...

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Détails bibliographiques
Auteurs principaux: Patel, Sandip, Morris, Stephen A., Adkins, Charles E., O’Beirne, Gerry, Taylor, Colin W.
Format: Artigo
Langue:Inglês
Publié: The National Academy of Sciences of the USA 1997
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC23558/
https://ncbi.nlm.nih.gov/pubmed/9326661
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