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Functional association between promoter structure and transcript alternative splicing

It has been assumed that constitutive and regulated splicing of RNA polymerase II transcripts depends exclusively on signals present in the RNA molecule. Here we show that changes in promoter structure strongly affect splice site selection. We investigated the splicing of the ED I exon, which encode...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Cramer, Paula, Pesce, C. Gustavo, Baralle, Francisco E., Kornblihtt, Alberto R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 1997
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Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23504/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9326631/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.21.11456
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