Single Nucleotide Polymorphisms That Cause Structural Changes in the Cyclic AMP Receptor Protein Transcriptional Regulator of the Tuberculosis Vaccine Strain Mycobacterium bovis BCG Alter Global Gene Expression without Attenuating Growth

Single nucleotide polymorphisms (SNPs) are present in the global transcriptional regulator cyclic AMP (cAMP) receptor protein (CRP) of the attenuated vaccine strain Mycobacterium bovis, bacillus Calmette-Guérin (BCG). We have found that these SNPs resulted in small but significant changes in the exp...

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Detalhes bibliográficos
Main Authors: Hunt, Debbie M., Saldanha, José W., Brennan, John F., Benjamin, Pearline, Strom, Molly, Cole, Jeffrey A., Spreadbury, Claire L., Buxton, Roger S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Molecular Pathogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2346674/
https://ncbi.nlm.nih.gov/pubmed/18332206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01410-07
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