Iminosugars in Combination with Interferon and Ribavirin Permanently Eradicate Noncytopathic Bovine Viral Diarrhea Virus from Persistently Infected Cells

We evaluated interferon (IFN) and ribavirin (RBV) as dual therapy and as part of triple-combination therapies with the iminosugars N-butyl-deoxynojirimycin (NB-DNJ), N-nonyl-deoxynojirimycin, and N-7-oxanonyl-6-deoxymethyl-galactonojirimycin. The ability of these compounds to clear bovine viral diar...

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Bibliographic Details
Main Authors: Woodhouse, Stephen D., Smith, Caroline, Michelet, Maud, Branza-Nichita, Norica, Hussey, Mark, Dwek, Raymond A., Zitzmann, Nicole
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2346636/
https://ncbi.nlm.nih.gov/pubmed/18316522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01181-07
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