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Roles of Nitric Oxide in Inflammatory Down-Regulation of Human Cytochromes P450

The purpose of this study was to determine the role of nitric oxide (NO) in the down-regulation of human CYP enzymes and mRNAs by an inflammatory stimulus in cultured human hepatocytes. We focused on CYP2B6, because previous studies showed that rat CYP2B proteins undergo an NO-dependent degradation...

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Autori principali: Aitken, Alison E., Lee, Choon-Myung, Morgan, Edward T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2346593/
https://ncbi.nlm.nih.gov/pubmed/18206661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2007.12.010
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