A functionally defined model for the M(2) proton channel of influenza A virus suggests a mechanism for its ion selectivity

The M(2) protein from influenza A virus forms proton-selective channels that are essential to viral function and are the target of the drug amantadine. Cys scanning was used to generate a series of mutants with successive substitutions in the transmembrane segment of the protein, and the mutants wer...

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Bibliographische Detailangaben
Hauptverfasser: Pinto, Lawrence H., Dieckmann, Gregg R., Gandhi, Chris S., Papworth, Carol G., Braman, Jeffrey, Shaughnessy, Margaret A., Lear, James D., Lamb, Robert A., DeGrado, William F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences of the USA 1997
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC23448/
https://ncbi.nlm.nih.gov/pubmed/9326604
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