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Nicotine is highly effective at producing desensitization of rat α4β2 neuronal nicotinic receptors

We examined desensitization by acetylcholine (ACh) and nicotine at the rat α4β2 neuronal nicotinic receptor stably expressed in HEK cells. For both agonists, the decay in response due to desensitization (‘onset’) was best fitted by the sum of two exponentials with the fast component dominant at conc...

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Bibliografske podrobnosti
Main Authors: Paradiso, K G, Steinbach, Joe Henry
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Science Inc 2003
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2343639/
https://ncbi.nlm.nih.gov/pubmed/14555718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2003.053447
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