A conserved pore-lining glutamate as a voltage- and chloride-dependent gate in the ClC-2 chloride channel

ClC-2 is a ubiquitously expressed, two-pore homodimeric Cl(−) channel opened by hyperpolarisation. Little is known about its gating mechanisms. Crystallographic and functional studies in other ClC channels suggest that a conserved glutamate residue carboxylate side-chain can close protopores by inte...

Full description

Saved in:
Bibliographic Details
Main Authors: Niemeyer, María Isabel, Cid, L Pablo, Zúñiga, Leandro, Catalán, Marcelo, Sepúlveda, Francisco V
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2003
Subjects:
Rapid Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2343633/
https://ncbi.nlm.nih.gov/pubmed/14617675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2003.055988
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items