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A conserved pore-lining glutamate as a voltage- and chloride-dependent gate in the ClC-2 chloride channel
ClC-2 is a ubiquitously expressed, two-pore homodimeric Cl(−) channel opened by hyperpolarisation. Little is known about its gating mechanisms. Crystallographic and functional studies in other ClC channels suggest that a conserved glutamate residue carboxylate side-chain can close protopores by inte...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2343633/ https://ncbi.nlm.nih.gov/pubmed/14617675 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2003.055988 |
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