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Effect of an N-terminus deletion on voltage-dependent gating of the ClC-2 chloride channel

ClC-2, a chloride channel widely expressed in mammalian tissues, is activated by hyperpolarisation and extracellular acidification. Deletion of amino acids 16–61 in rat ClC-2 abolishes voltage and pH dependence in two-electrode voltage-clamp experiments in amphibian oocytes. These results have been...

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Detalhes bibliográficos
Main Authors: Varela, Diego, Niemeyer, María Isabel, Cid, L Pablo, Sepúlveda, Francisco V
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2290594/
https://ncbi.nlm.nih.gov/pubmed/12381811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2002.026096
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