IL-21 mediates apoptosis through up-regulation of the BH3 family member BIM and enhances both direct and antibody-dependent cellular cytotoxicity in primary chronic lymphocytic leukemia cells in vitro

Interleukin-21 (IL-21) is a recently identified γ-chain receptor cytokine family member that promotes B-cell apoptosis as well as activation of innate immune system. Based on this, we hypothesized that IL-21 might enhance the apoptosis induced by fludarabine and rituximab and also play a role in aug...

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Hlavní autoři: Gowda, Aruna, Roda, Julie, Hussain, Syed-Rehan A., Ramanunni, Asha, Joshi, Trupti, Schmidt, Susan, Zhang, Xiaoli, Lehman, Amy, Jarjoura, David, Carson, William E., Kindsvogel, Wayne, Cheney, Carolyn, Caligiuri, Michael A., Tridandapani, Susheela, Muthusamy, Natarajan, Byrd, John C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2008
Témata:
Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2343602/
https://ncbi.nlm.nih.gov/pubmed/18182577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-07-099531
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