IL-21 mediates apoptosis through up-regulation of the BH3 family member BIM and enhances both direct and antibody-dependent cellular cytotoxicity in primary chronic lymphocytic leukemia cells in vitro

Interleukin-21 (IL-21) is a recently identified γ-chain receptor cytokine family member that promotes B-cell apoptosis as well as activation of innate immune system. Based on this, we hypothesized that IL-21 might enhance the apoptosis induced by fludarabine and rituximab and also play a role in aug...

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Bibliografische gegevens
Hoofdauteurs: Gowda, Aruna, Roda, Julie, Hussain, Syed-Rehan A., Ramanunni, Asha, Joshi, Trupti, Schmidt, Susan, Zhang, Xiaoli, Lehman, Amy, Jarjoura, David, Carson, William E., Kindsvogel, Wayne, Cheney, Carolyn, Caligiuri, Michael A., Tridandapani, Susheela, Muthusamy, Natarajan, Byrd, John C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2008
Onderwerpen:
Neoplasia
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2343602/
https://ncbi.nlm.nih.gov/pubmed/18182577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-07-099531
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