IL-21 mediates apoptosis through up-regulation of the BH3 family member BIM and enhances both direct and antibody-dependent cellular cytotoxicity in primary chronic lymphocytic leukemia cells in vitro

Interleukin-21 (IL-21) is a recently identified γ-chain receptor cytokine family member that promotes B-cell apoptosis as well as activation of innate immune system. Based on this, we hypothesized that IL-21 might enhance the apoptosis induced by fludarabine and rituximab and also play a role in aug...

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Detalhes bibliográficos
Main Authors: Gowda, Aruna, Roda, Julie, Hussain, Syed-Rehan A., Ramanunni, Asha, Joshi, Trupti, Schmidt, Susan, Zhang, Xiaoli, Lehman, Amy, Jarjoura, David, Carson, William E., Kindsvogel, Wayne, Cheney, Carolyn, Caligiuri, Michael A., Tridandapani, Susheela, Muthusamy, Natarajan, Byrd, John C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2343602/
https://ncbi.nlm.nih.gov/pubmed/18182577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-07-099531
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