Phagocytosis and intracellular killing of MD-2 opsonized Gram-negative bacteria depend on TLR4 signaling

Both Toll-like receptor 4 (TLR4)– and MD-2–deficient mice succumb to otherwise nonfatal Gram-negative bacteria inocula, demonstrating the pivotal role played by these proteins in antibacterial defense in mammals. MD-2 is a soluble endogenous ligand for TLR4 and a receptor for lipopolysaccharide (LPS...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Jain, Vishal, Halle, Annett, Halmen, Kristen A., Lien, Egil, Charrel-Dennis, Marie, Ram, Sanjay, Golenbock, Douglas T., Visintin, Alberto
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Hematology 2008
Pynciau:
Immunobiology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2343597/
https://ncbi.nlm.nih.gov/pubmed/18203953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-11-126862
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