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Converting a transmembrane receptor to a soluble receptor: Recognition domain to effector domain signaling after excision of the transmembrane domain

The bacterial aspartate receptor was reconstructed to eliminate the transmembrane domain, thus connecting the recognition domain directly to the effector domain. The resulting soluble receptor folded correctly and was no longer an integral membrane protein. Upon aspartate binding, this soluble recep...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Principais autores: Ottemann, Karen M., Koshland, Daniel E.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 1997
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23415/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9326586/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.21.11201
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