Hinge and Transmembrane Domains of Chimeric Antigen Receptor Regulate Receptor Expression and Signaling Threshold

Chimeric antigen receptor (CAR)-T cells have demonstrated significant clinical potential; however, their strong antitumor activity may cause severe adverse effects. To ensure efficacy and safe CAR-T cell therapy, it is important to understand CAR’s structure–activity relationship. To clarify the rol...

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Váldodahkkit:	Kento Fujiwara, Ayaka Tsunei, Hotaka Kusabuka, Erika Ogaki, Masashi Tachibana, Naoki Okada
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	MDPI AG 2020-05-01
Ráidu:	Cells
Fáttát:	chimeric antigen receptor CAR-T cell therapy structure-activity relationship hinge domain transmembrane domain
Liŋkkat:	https://www.mdpi.com/2073-4409/9/5/1182
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