Hinge and Transmembrane Domains of Chimeric Antigen Receptor Regulate Receptor Expression and Signaling Threshold

Chimeric antigen receptor (CAR)-T cells have demonstrated significant clinical potential; however, their strong antitumor activity may cause severe adverse effects. To ensure efficacy and safe CAR-T cell therapy, it is important to understand CAR’s structure–activity relationship. To clarify the rol...

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Hlavní autoři:	Kento Fujiwara, Ayaka Tsunei, Hotaka Kusabuka, Erika Ogaki, Masashi Tachibana, Naoki Okada
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2020-05-01
Edice:	Cells
Témata:	chimeric antigen receptor CAR-T cell therapy structure-activity relationship hinge domain transmembrane domain
On-line přístup:	https://www.mdpi.com/2073-4409/9/5/1182
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