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Implication of the Transmembrane Domain in the Interleukin 10 Receptor Platform Oligomerisation

Interleukin 10 (IL-10) exerts anti-inflammatory and immune regulatory roles through its fixation to the IL-10 receptor (IL-10R). The two subunits (IL-10Rα and IL-10Rβ) organise themselves to form a hetero-tetramer to induce the activation of the transcription factor STAT3. We analysed the activation...

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Principais autores: Thomas Kuntzel, Caroline Spenlé, Lucas D. Pham-Van, Dafni Birmpili, Aurélien Riou, Aurore Loeuillet, Imane Charmarke-Askar, Dominique Bagnard
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2023-05-01
Serier:Cells
Fag:
transmembrane domain
interleukin 10
peptide
macrophage
Online adgang:https://www.mdpi.com/2073-4409/12/10/1361
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