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Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

Human P-glycoprotein (Pgp) confers multidrug resistance to cancer cells by ATP-dependent extrusion of a great many structurally dissimilar hydrophobic compounds. The manner in which Pgp recognizes these different substrates is unknown. The protein shows internal homology between its N- and C-termina...

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Main Authors: Dey, Saibal, Ramachandra, Muralidhara, Pastan, Ira, Gottesman, Michael M., Ambudkar, Suresh V.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 1997
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC23414/
https://ncbi.nlm.nih.gov/pubmed/9380680
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