The orphan nuclear receptor LXRα is positively and negatively regulated by distinct products of mevalonate metabolism

LXRα is an orphan member of the nuclear hormone receptor superfamily that displays constitutive transcriptional activity. We reasoned that this activity may result from the production of an endogenous activator that is a component of intermediary metabolism. The use of metabolic inhibitors revealed...

Popoln opis

Bibliografske podrobnosti

izdano v:	Proc Natl Acad Sci U S A
Principais autores:	Forman, Barry Marc, Ruan, Benfang, Chen, Jasmine, Schroepfer, George J., Evans, Ronald M.
Format:	Artigo
Jezik:	Inglês
Izdano:	National Academy of Sciences 1997
Teme:	Biological Sciences
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23411/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9380679/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.20.10588
Oznake:	Označite Brez oznak, prvi označite!